REFERENCES
PDRN Mechanics
1. PDRN of mean molecular weight 360kD selectively bonds with A2 receptor and creates anti - inflammatory effect.
2.At this moment, various growth factors are secreted and starts to regenerate damaged tissues.
3. It leads to new birth of blood vessels of damaged parts by secreting VEGF.
4. It also leads to fast DNA synthesis and cell regeneration with less energy through salvage pathway.
Principle of PDRN Therapy
If PDRN is directly penetrated into the skin layer rather than simply applied to the skin, the effect can be expected to be about 200 times greater, and the effect of low-molecular-weight PDRN is even greater.
When PDRN is activated, not only does the dermal layer of the skin become thicker (1), but the skin can also be compacted into a dense tissue (2).
(1)
(2)
Why PDRN
PDRN (PolyDeoxyRiboNucleotide) protect cells from UV-induced-DNA damage. Exposure of human dermal fibroblasts to ultraviolet B radiation causes accumulation of dangerous photoproducts such as cyclobutene pyrimidine dimers
(CPDS) PDRN addition to the cell culture immediately after irradiation resulted in p53 protein activation and in enhancing DNA repair likely due to the priming of the salvage pathway.
ISO 22716
No matter how good quality raw materials are used, if the product is not made correctly, the ingredients are
contaminated in the process and can cause serious harm tothe skin. Although CLEON is a licensed cosmetic product, it is the highest quality product that has undergone sterilization and germ testing in the latest Clean System, and is harmless even when injected into the skin because it does not use preservatives.